Fri May 23 2025

44 articles - From Friday May 16 2025 to Friday May 23 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Inflamm Bowel Dis

Developing IBD Outcome Effect Size Thresholds to Inform Research, Guidelines, and Clinical Decisions.

This is the first study to develop a consensus on magnitude thresholds for outcomes in IBD. These thresholds have been used in the development of the 2024 British Society of Gastroenterology guidelines for the management of IBD but can and should also be used by study designers and, most importantly, by clinicians when discussing evidence with patients as part of shared decision making. Future work to validate these findings globally and with other groups, including patients, is needed.

Pubmed   Journal   ReadQx 


Meta-analysis

meta-analyses and systematic reviews

Am J Clin Nutr

Industry study sponsorship and conflicts of interest on the effect of unprocessed red meat on cardiovascular disease risk: a systematic review of clinical trials.

Our findings highlight that using animal protein as a comparator in industry-funded studies, with quality of evidence rated as very low to low, may underestimate the cardiovascular benefits of reducing red meat intake. Most studies without conflicts of interest with the red meat industry suggested an unfavorable effect of unprocessed red meat consumption on risk factors for cardiovascular disease.

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Pancreatology

Chronic pancreatitis and extra pancreatic cancers- A systematic review and meta analysis.

Patients with CP have an increased risk of developing EP cancers compared to patients without CP, in particular lung and liver cancer which had the highest relative risk. Shared risk factor modifications, such as smoking cessation and alcohol reduction, could lower the risk of common EP cancers. Further, implementing non-invasive screening measures may aid in early diagnosis in this high-risk group.

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Minimally invasive versus open distal pancreatectomy for pancreatic Tumors: An updated meta-analysis and meta-regression.

MIDP offers superior outcomes in procedure efficacy, surgical and postoperative outcomes compared to ODP. These findings highlight MIDP as a safe and effective alternative for pancreatic surgery, supported by robust subgroup and sensitivity analyses.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

A Novel Nutritional Assessment Tool Combining the mNUTRIC Score and the GLIM Criteria with Prognostic Value for In-Hospital Mortality in Critically Ill Patients : A Single-Center Retrospective Cohort Study.

This novel nutritional assessment tool had strong prognostic value in being associated with in-hospital mortality. Prospective validation with an external dataset is warranted. A comprehensive nutritional assessment of the current status and future risk at ICU admission could be the most critical factor in assessing the prognosis of critically ill patients.

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Association of sociodemographic factors and a healthy and sustainable dietary pattern in adult population in Mexico, United States and Canada: a cross-sectional study.

Mexico, the US, and Canada have an unhealthy and high environmental impact dietary pattern. The groups with lower compliance are men, younger individuals, and those with lower educational attainment.

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Dietary patterns, serum metabolites and risk of cardiovascular disease in US Hispanic/Latino adults: a prospective analysis of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Healthier diet patterns and related serum metabolite profile were associated with lower risk of CVD in US Hispanic/Latino adults.

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Effect of age and sex on the urinary elimination of a single dose of mixed flavonoids: results from a single-arm intervention in healthy UK adults.

Total elimination recovery of (poly)phenols was relatively consistent across age and sex groups, while elimination kinetics differed substantially; possibly resulting from differences in intestinal transit time or kidney clearance. Assuming (poly)phenol metabolites have varying biological activities, establishing dose response relationships, and defining metabolite profiles in population subgroups is required to inform the future development of dietary flavonoid/(poly)phenol recommendations. Clinical trial registry NCT01922869.

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Inflamm Bowel Dis

Biological Ageing and the Risk of Inflammatory Bowel Disease: Exploring the Role of Lifestyle and Genetic Susceptibility in a Nationwide Prospective Study.

PhenoAge acceleration may serve as a useful biomarker for identifying high-risk individuals, offering potential for integration into targeted prevention strategies and personalized treatment approaches for IBD.This study explores how accelerated biological aging (PhenoAge acceleration) and genetic susceptibility influence the risk of inflammatory bowel disease. Findings indicate that higher PhenoAge acceleration and genetic risk scores significantly increase the likelihood of developing ulcerative colitis and Crohn's disease.

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Decreased Fecal Nicotinamide and Increased Bacterial Nicotinamidase Gene Expression in Ulcerative Colitis Patients.

These findings suggest that gut microbiota dysbiosis contributes to reduced vitamin B3 metabolism in UC patients. The study highlights the potential of replenishing vitamin B3 metabolic pathways as a novel therapeutic approach for UC treatment.

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SPH3127 (Sitokiren), a Novel Renin Inhibitor, Suppresses Colitis Development in Mouse Models of Experimental Colitis.

These results demonstrate that SPH3127 is able to effectively block colitis development in mouse experimental colitis models. Its anti-colitogenic activity is achieved at least in part by suppressing mucosal TH1 and TH17 activation while promoting IL-10 production from mucosal CD25+ T cells, thus forming an anti-inflammatory environment in the colonic mucosa.

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Six-Year Observation Data Reveal Reduction in Concomitant Steroid Overuse for Inflammatory Bowel Disease in Germany.

This study provides real-world insights into the patterns of OCS use and overuse in IBD patients. The continued reliance on OCS is highlighted, particularly in CD patients and younger age groups. Notably, steroid overuse has decreased significantly over the last 6 years.

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Therapeutic Potential and Translational Challenges for Bacterial Extracellular Vesicles in Inflammatory Bowel Disease.

In this review, we summarize the work done to date establishing the potential of BEVs to provide the therapeutic benefits in IBD and discuss the hurdles BEVs must overcome to achieve clinical translation. We also consider future directions for BEV therapeutics, especially treatment potential for necrotizing enterocolitis (NEC), which shares similarities in pathophysiology with IBD.

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Unravelling the Relationship Between Obesity and Inflammatory Bowel Disease.

Obesity has been demonstrated to be associated with an attenuated response to immunomodulators and biological agents, as well as higher rates of peri-operative surgical complications. A better understanding of the relationship between obesity and IBD can be applied to clinical decision-making in personalizing treatment plans, promoting weight loss in patients with obesity, and identifying areas of future research.

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Usefulness of Prostaglandin E-Major Urinary Metabolite in Monitoring Crohn's Disease Activity: A Prospective Cross-Sectional Study.

PGE-MUM is a biomarker that can reflect endoscopic activity in patients with CD and may be particularly useful in small intestinal lesions.

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J Crohns Colitis

Deucravacitinib in Patients With Inflammatory Bowel Disease: 12-Week Efficacy and Safety Results From Three Randomized Phase 2 Studies in Crohn's Disease and Ulcerative Colitis.

Deucravacitinib at multiple doses did not demonstrate significant clinical benefit vs placebo in moderately to severely active Crohn's disease or ulcerative colitis. Deucravacitinib was safe and well-tolerated.

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Distinct perturbances in metabolic pathways associate with disease progression in inflammatory bowel disease.

Specific metabolites and pathways are associated with disease progression in IBD, highlighting potential prognostic biomarkers and relevant pathways.

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Restoring Prostacyclin/PGI2-PTGIR Signaling Alleviates Intestinal Fibrosis in Crohn's Disease via Fibroblast-specific YAP/TAZ Inhibition.

The antifibrotic effects of PGI2-PTGIR signaling are impaired in CD. Restoring PGI2-PTGIR signaling is a pharmacologically tractable and cell-selective approach to targeting YAP/TAZ via PTGIR, which reverses intestinal fibrosis.

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Risk of colectomy is decreasing among newly diagnosed Finnish ulcerative colitis patients.

The risk of colectomy in UC patients has decreased in the 21st century.

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Serum Biomarkers of Collagen Remodeling are Associated with Intestinal Fibrosis and Differentiates Stenotic from Luminal Crohn's Disease Patients: A Pre- and Post-Resection Longitudinal Study.

Collagen markers distinguished stenosing from luminal CD, and they correlated to histological fibrosis and chronic inflammation promising for understanding ECM remodeling. This study highlights the need for extended follow-up to assess long-term stenosis-related outcomes.

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The angiotensin receptor blocker, losartan, reduces inflammation and fibrosis, and prevents relapse of fibrosis after steroid-induced remission, in mice prone to Crohn's disease-like ileitis.

Losartan, and other drugs targeting the renin-angiotensin system, may serve as an effective treatment to successfully dampen intestinal fibrosis during active inflammation, as well as prevent its progression after corticosteroid-induced remission in Crohn's patients.

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Liver Transpl

From embedded interprofessional clinics to expanded alcohol-associated liver disease programs.

Drawing from analogous patient populations served by collaborative models in primary care and comprehensive eating disorder treatment, the expanded ALD care framework proposes practical strategies toward specific innovations: equipoise between biomedical and psychosocial care elements, increased clinician number and reach, long term patient relationships, harm reduction and palliative care, outreach to external agencies and clinicians, and enhanced support for patients and families. The article also defines attributes of innovative healthcare systems which support expanded ALD care.

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Occult multifocal and incidental hepatocellular carcinoma: An analysis of long-term survival and risk factors at a single liver transplant center.

In patients with known HCC prior to LT, presence of omHCC is common and associated with inferior post-LT survival and higher recurrence rates. The development of improved radiographic and serum biomarkers which more accurately reflect explant tumor burden may improve patient selection and post-LT outcomes.

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Social Determinants of Health are Associated with Liver Transplant Evaluation and Listing in a Safety-Net Referral Cohort.

A sensitivity analysis including an existing multicenter cohort re-demonstrated the significance of residence, adequacy of social support, and MELD score in probability of listing. Social determinants of health were key to successful evaluation and listing for LT among referred SNH patients and provide targets for intervention.

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Pancreas

Pancreatic Fat Infiltration: A Key Marker in The Metabolic Continuum.

PFI is a relevant metabolic marker associated with central obesity, insulin resistance, and increased pancreatic stiffness. These findings support the potential of transabdominal 2D-SWE as a non-invasive tool for detecting early pancreatic structural, particularly in patients with T2D. Longitudinal studies are warranted to clarify its role in predicting pancreatic dysfunction and metabolic disease progression.

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Perioperative Pain Management for Complex Pancreatic Resections for Patients with Chronic Pancreatitis.

Ketamine provided similar opioid sparing analgesia compared to opioid epidurals. Ketamine is a promising adjunctive analgesic in patients with chronic pancreatitis.

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Prognostic Significance of ABO Blood Type in Patients with Advanced Pancreatic Cancer Treated with Nab-Paclitaxel Plus Gemcitabine.

Patients with the B blood type had a markedly poorer prognosis and a higher prevalence of sarcopenia. Patients who have APC with the B blood type may require additional supportive treatment for sarcopenia.

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Protein N-Glycosylation Traits Combined with CA19-9 Accurately Distinguish Pancreatic Cancer Cases From Healthy Controls and Benign Pancreatic Diseases.

Both plasma NGTs and CA19-9 distinguish PDAC from a diverse-control cohort. The accuracy further improves when these readouts are combined, showing promise for future early detection methods.

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Risk of Myocardial Infarction and Stroke after a First Episode of Acute Pancreatitis: A Self-Controlled Case Series Study.

The IRR for stroke during the risk interval was 2.12 (95% CI, 1.74-2.58), peaking in the first 10 days (IRR, 3.40; 95% CI, 2.33-4.96) and gradually declining. Our study reveals a temporary increase in the risk of myocardial infarction and stroke after hospitalization for a first episode of acute pancreatitis.

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Surgical Resection of Murine PDAC Alters Hepatic Metastases and Immune Microenvironment.

Collectively, we describe a preclinical resection model that offers a means to investigate MRD. Using this model, we delineated effects of surgical resection on metastatic outgrowth and uncovered a protective link between the postoperative hepatic eosinophilia and further metastatic progression.

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Pancreatology

Comparison of thrombosis risk in patients undergoing purified and non-purified islet cell transplantation.

While PVT is a relatively rare event in both purified and non-purified IAT when peri-operative and post-operative full-dose heparinization is administered, there remains a clinical difference in PVT formation between purified and non-purified IATs. Although bleeding risk may potentially be mitigated by a reduction in the duration of full dose heparinization without a corresponding risk in PVT rate, further investigation is warranted.

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Pancreatic adenocarcinoma patients with pain have abnormal central pain processing.

P-QST revealed abnormal central pain processing in PDAC patients compared to healthy controls, which may have implications for pain management.

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Suboptimal adherence to surveillance in high-risk individuals for pancreatic cancer at a tertiary care academic center: Lessons from real-world surveillance patterns.

It is difficult to achieve high adherence rates for annual pancreatic cancer screening of HRIs as recommended by the latest guidelines. Age and screening modality may be factors that contribute to adherence difficulty.

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The impact of delayed graft function after pancreas transplantation on clinical outcomes and survival.

Of note, in the multivariable analysis pDGF showed a strong trend towards worse graft survival without reaching statistical significance (HR:2.33, 95 % CI: 0.95-5.82; p = 0.069) CONCLUSION: pDGF represents a common condition, depending both from donor and recipient conditions. Its clinical impact concerns the early postoperative stay and the long-term graft survival as well.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

Three Decades of the Mediterranean Diet Pyramid: A Narrative Review of Its History, Evolution, and Advances.

The development of the MedDiet pyramid 30 years ago inspired the creation of the Asian, African, and Latin American Heritage Diet Pyramids. Despite robust evidence, further studies are needed to evaluate the long-term effectiveness and adaptability of the MedDiet across diverse populations, cultural settings, and food environments.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

J Crohns Colitis

Correction to: Volume 18, Supplement 1.

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Liver Transpl

"You're hot then you're cold": Can we omit recooling after NMP?

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Letter to the Editor: Limitations of MRI-serum-based scoring in liver transplant rejection assessment.

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Outcomes of kidney after liver transplantation by induction type, Inter-Transplant interval, and immunologic risk: A UNOS analysis.

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Reply: Limitations of MRI-serum-based scoring in liver transplant rejection assessment.

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Pancreas

Not Dead Yet: Managing the Abdominal Catastrophe in Necrotizing Pancreatitis.

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The Financial Impact of Drugs Utilized for Medical Management of Chronic Pancreatitisrelated Symptoms.

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Unaddressed Financial Barriers to Pancreatic Enzyme Replacement Therapy in Patients with GEPNENs and EPI.

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Letters&Replies

Letters to the editors and authors’ replies

Pancreatology

Performance of a novel three-prong asymmetric tip needle in EUS-guided tissue sampling of pancreatic solid Lesions: Implications for diagnosis and molecular profiling.

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